Troubleshooting

MonolixSuite is safe but has not been reviewed by Apple. You can override the security settings to install Monolix 2023R1 following these steps:

• Open Finder
• Locate monolixSuite2023R1.app where you have downloaded and extracted it
• Control+Click the monolixSuite2023R1.app
• Select Open
• Click Open

Monolix2023R1 should now be saved as an exception in the security settings, allowing to open it in the future.

On Mac, when initializating the lixoftConnectors, I get an error “unable to load shared object”

MonolixSuite has not been compiled for M1 chips. To use the lixoftConnectors, you need to install and use the ‘x86_64’ version of R that you can install from https://cran.r-project.org/bin/macosx/

Does MonolixSuite work on Mac OS with M1 chips?

MonolixSuite has not been compiled for M1 chips. To use it with the GUI, you need to use it with Rosetta.
To use the lixoftConnectors, you need to install and use the ‘x86_64’ version of R that you can install from https://cran.r-project.org/bin/macosx/

@echo off
cd %~dp0\..\lib
start "monolix" /B "monolix.exe" --disable-gpu %1 %2 %3 %4 %5 %6 %7 %8 %9
cd %~dp0

• save the file
• reopen Monolix

When launching an application of the MonolixSuite on Windows, I get the error “Cannot find cmd.exe in current system path”

If you get the following error message: Cannot find cmd.exe in current system path PATH, please follow the steps below to add C:/Windows/system32, which contains the cmd.exe executable, to the PATH.

• from file browser, right click on Computer > Properties. You arrive in control panel > system and security > system.
• click advanced system settings (on the left of the window)
• click environment variables in the pop-up window
• in the system variables, edit the Path variable:

• add

  C:\Windows\system32;

  at the beginning

• save and retry

On MacOS, when trying to open a project created on Windows, I get the error “Impossible to open file ‘dataset.csv’ in text mode.”

After opening the project created on Windows machine, the error message “Impossible to open file ‘dataset.csv’ in text mode.” may appear. To overcome this error, start MonolixSuite in the following way:
– right click on the application icon and click on Show package content,
– open MacOS subfolder inside Contents folder,
– start MonolixSuite by double clicking on monolixsuite.

When trying to load any project, I get “Error during module building:Calling the build setup failed and returned“.

This message means that the compilation of the model has failed.
On Mac OS, make sure that XCode has been installed and launched at least once, as specified in the requirements of the download page.
On Windows, the most common cause is special characters (including dots and spaces) in the windows session username. To modify the path where the compiled model is stored to avoid using the username, please follow this procedure:
1) Go the installation folder (usually C:\ProgramData\Lixoft\MonolixSuiteXXXX, where XXXX is the MonolixSuite version). ProgramData is usually a hidden folder, but it is possible to just copy and paste the path in the path bar at the top of the Windows Explorer.
2) Once you are in the installation folder, go to the config folder and open the system.ini file in a text editor such as WordPad or Notepad++.
3) Modify the [path] section in the following way:
[path]
enforced-modules-directory = C:/Temp/lixoftmodules
4) Close and reopen Monolix.

On Windows, Monolix crashes while generating the diagnostic plots

This can be due to the use of the GPU. Follow the procedure below to disable the use of the GPU (this should not impact performance):

• Open the file monolix.bat located in C:\ProgramData\Lixoft\MonolixSuiteXXX\bin (where XXX is your MonolixSuite version) in a text editor
• Add the option --disable-gpu as shown below:

@echo off
cd %~dp0\..\lib
start "monolix" /B "monolix.exe" --disable-gpu %1 %2 %3 %4 %5 %6 %7 %8 %9 
cd %~dp0

• Save the monolix.bat file
• Relaunch Monolix

Resolution and display

Remote access using direct rendering is not working

Our interfaces are using OpenGL technology. This implies that the remote access cannot use direct rendering (the OpenGL application sends instructions directly to the local hardware bypassing the target X server).

An indirect rendering should be used, i.e. the remote application sends instructions to the X server which transfers them to the graphics card. It is possible to do that with an ssh application, but it needs a dedicated configuration depending on the machine and the operating system. Other applications such as VNC or Remina can be used for an indirect rendering.

The graphical user interface appears with too high or too low resolution

• open Monolix
• load any project from the demos
• in the menu, go to Settings > Preferences and disable the “High dpi scaling” in the Options.
• close Monolix
• restart Monolix

The Observed data plot or VPC plot is emtpy or with non-appropriate axis limits

The problem appears after having clicked “Export > Export charts settings as default” on a previous project where the y-axis limits were different and this is now applied as default. It is possible to delete the default setting corresponding to the axis limits in the following way:

• Open the file C:/Users/<username>/lixoft/monolix/monolix2023R1/config/settings.default in a text editor
• Delete the following lines:

  VPCContinuousyInterval= ...
  outputPlotyInterval= ...

• Save the file
• Reopen your project